窄谱中波紫外线联合干扰素α-2b治疗蕈样肉芽肿对血清趋化因子CCL27的影响

Effects of narrowband-ultraviolet B combined with interferon α-2b on serum CCL27 level of mycosis fungoides patients

目的观察窄谱中波紫外线(NB-UVB)联合干扰素(IFN)-α-2b治疗蕈样肉芽肿(MF)的临床疗效,并比较治疗前后患者血清趋化因子CCL27水平。方法对17例MF患者行重组人IFNα-2b肌肉注射联合NB-UVB照射治疗,于治疗前后分别采集患者血清,利用酶联免疫吸附试验(ELISA)测其血清CCL27浓度,以16例健康人血清为对照组。结果治疗前MF患者CCL27血清水平高于健康对照组(P<0.01),联合治疗后17例患者完全缓解率(CCR)为64.71%,部分缓解率(PCR)为29.41%,有效率(CCR+PCR)为94.12%;其治疗后的血清CCL27水平较治疗前显著下降(P<0.01)。结论 NB-UVB照射联合IFNα-2b肌肉注射治疗蕈样肉芽肿是一种安全有效的方法,可降低患者血清CCL27水平。

Objective To observe the efficacy of narrowband-ultraviolet B（NB-UVB） combined with interferon α-2b in the treatment of mycosis fungoides（MF） patients and evaluate the effects of the procedures on serum CCL27 level.Methods Seventeen patients with MF were treated with NB-UVB combined with interferon α-2b.Patient′s sera were collected before and after treatment.Enzyme-linked immunosorbent assay（ELISA） was used to measure serum CCL27 level.The control group consisted of sixteen healthy subjects.Results Serum CCL27 level of MF patients was significantly higher than that of the control group（P0.01）.The rate of complete clinical remission（CCR）,partial clinical remission（PCR） and total response rate（CCR＋PCR） were 64.71%,29.41%,and 94.12%,respectively.Serum CCL27 level significantly decreased after the combined treatment（P0.01）.Conclusion NB-UVB combined with interferon α-2b in the treatment of MF patients is an effective and safe therapy which can decrease the serum CCL27 level.