祛风止痒颗粒抗Ⅰ型变态反应作用及其机制研究

Study of Qufengzhiyang Granule on anti-type Ⅰ allergic activity and It's pharmacological mechanisms

目的:研究祛风止痒颗粒抗Ⅰ型变态反应的作用及其机制。方法:采用大鼠同种被动皮肤过敏实验(PCA反应),观察祛风止痒颗粒对Ⅰ型变态反应的作用;通过ELISA法检测祛风止痒颗粒对Ⅰ型变态反应模型大鼠血清中IL-4、IFN-γ、IgE的含量变化的影响。结果:祛风止痒颗粒可抑制大鼠PCA反应;降低Ⅰ型变态反应模型大鼠血清中IL-4、IgE的含量、增加血清中IFN-γ的含量。结论:祛风止痒颗粒可对抗Ⅰ型变态反应,其机制可能是通过促进IFN-γ分泌,减少IL-4、IgE含量,调节Th1/Th2细胞因子水平来完成的。

Objective： To study the effect of Qufengzhiyang Granule on anti-type I allergic activity and It’s pharmacological mechanisms.Methods： The effects of anti-type I allergic activity on rats of Qufengzhiyang Granule were observed by passive cutaneous anaphylaxis;The effects of Qufengzhiyang Granule on contents of IL-4、IFN-γand IgE in cutaneous anaphylaxis reaction rats model were detected with ELISA.Results ：Qufengzhiyang Granule can inhibit the passive cutaneous anaphylaxis,reduce the contents of IL-4、IgE and increase the IFN-γin cutaneous anaphylaxis reaction rats model.Conclusion： Qufengzhiyang Granule has the effect of anti-type I allergic activity,and its mechanism might be related with promoting IFN-γsecretion,reducing IL-4、IgE contents and regulating the levels of Th1/Th2 cytokines.