小儿咳喘颗粒防治急性肺损伤作用研究

Research for protective effect of Xiao'er Kechuan Granules on acute lung injury

目的:研究小儿咳喘颗粒抗炎作用并初步探讨其作用机制。方法:采用大鼠足跖皮下注射角叉菜胶致急性炎症模型,观察小儿咳喘颗粒对致炎后大鼠足肿胀的影响;采用气管内滴入脂多糖诱导小鼠急性肺损伤,观察药物对小鼠肺组织TNF-α、IL-10含量的影响。结果:小儿咳喘颗粒在多个时间点均可减轻大鼠足肿胀;并明显降低ALI小鼠TNF-α水平(P<0.01),可增加模型小鼠肺组织匀浆中IL-10含量。结论:小儿咳喘颗粒有明显的抗炎作用,对急性肺损伤有一定的保护作用。

Objective ：To study the protective effect of Xiao’er Kechuan granules on acute lung injury and its primary mechanism.Methods ： Paw edema was induced by carrageenan to study the inhibitory effect of Xiao’er Kechuan graules on non-specific acute inflammation;Acute lung injury model mice were induced by lipopolysaccharides dripping,lung water content was calculated and TNF-α,IL-10 contents in the lung tissue were measured.Results： Xiao’er Kechuan granules could significantly inhibit paw edema in rat induced by carrageenin at diffrent time points;Xiao’er Kechuan granules at 4.5 and 9g/kg could reduce TNF-α content（P 〈0.01） as well as dexamethasone.Xiao’er Kechuan granules at 9g/kg could increase IL-10 content（P 〈0.05）.Conclusion： Xiao’er Kechuan granules have significantly protective effect on acute lung injury.