小儿咳喘颗粒平喘试验的研究

Pharmacodynamic studies on panting-calming actions of Xiao'erkechuan Granules

目的:研究小儿咳喘颗粒平喘的作用及机制。方法:采用乙酰胆碱-组胺引喘法及改进肺溢流实验方法,观察小儿咳喘颗粒对豚鼠引喘的潜伏期、倒扑时间,气胸大鼠被动吸气所需正压力上升的影响。结果:小儿咳喘颗粒3g/kg和6g/kg剂量组可明显延长乙酰胆碱-组胺所致的喘息潜伏时;3g/kg剂量组对大鼠在引喘后30 s表现出明显的抑制呼吸阻力增加的作用。结论:小儿咳喘颗粒有明显的平喘作用,其平喘作用可能与延长喘息潜伏时和降低呼吸阻力有关。

Objective： To investigate the effect of Xiao’erkechuan granules in asthmatic animals.Methods ：Asthmatic models were induced by acetylcholine and histamine in guinea pig and rat.We observed latent period and falling time of asthmatic guinea pig.We also investigated inhibition of respiratory resistance of drug in rats in order to study the mechanism.Results： Xiao’erkechuan granules 3g/kg and 6g/kg groups significantly prolonged the latent period in asthmatic guinea pig（P〈0.05） and inhibited respiratory resistance in rats（P〈0.01）.Conclusion： Xiao’erkechuan granules has panting-calming effects which is associated with prolongation of asthmatic latent period and deceasing respiratory resistance.