褪黑素联合化疗对肺癌患者褪黑素水平及免疫功能的影响

Effects of melatonin plus chemotherapy on the serum concentration of melatonin and the immune funetion of non-small cell lung cancer patients

目的:了解褪黑素(MT)联合化疗对非小细胞肺癌(NSCLC)患者MT水平及免疫功能的影响。方法:选择经病例确诊的45例NSCLC患者,随机分为两组,对照组(22例)予以顺铂联合长春瑞滨(NP)化疗。试验组(23例)予以NP联合口服MT胶囊,连续化疗2个周期,检测化疗前后患者T细胞亚群+NK及血清MT水平。结果:化疗后,对照组0:00时MT下降(t=5.563,P=0.000),而试验组MT水平升高(t=-4.307,P=0.000),且高于对照组化疗后水平(t=-4.307,P=0.000)。CD4+、NK细胞的百分率较对照组化疗后明显升高(t=-2.672,P=0.012;t=-4.266,P=0.000),而CD8+下降(t=1.980,P=0.044)。结论:MT联合化疗,可以阻止血清MT水平的下降,可以调节肺癌患者的免疫功能。

OBJECTIVE：To understand the effects of melatonin plus chemotherapy on the serum concentration of melatonin and the immune function of the patients with non-small cell lung cancer.METHODS：Forty-five patients confirmed were divided into two groups randomily to receive chemotherapy （NP） alone （22 cases） and chemotherapy （NP） with melatonin （23 cases）,The melatonin capsules were used without interruption in every day during two chemotherapy periods.The serum concentration of melatonin,the change of cell mediated immunity and NK were detected before and after the chemotherapy.RESULTS：The circadian rhythm exsited in each group.The serum level of the melatonin at 0：00 of control group was significantly lower after two cycles of chemotherapy （t=5.563,P=0.000）,but significantly higher in the study group （t=-4.307,P=0.000）,and higher than that of the control group （t=-4.307,P=0.000）.The percentages of CD4＋ and NK of the study group were significantly higher than those of the control group （t=-2.672,P=0.012; t=-4.266,P=0.000）,while the percentage of CD8＋ was significantly lower after chemotherapy （t=1.980,P=0.044）.CONCLUSION：The melatonin plus chemotherapy could prevent the decline of serum concentration of melatonin and mediate the immune function of the patients with lung cancer patients.