广州部分早产儿血清甲状腺激素水平与胎龄、出生体重的关系

Relationship of Thyroid Hormones to Gestational Age and Birth Weight in Preterm Infants.

目的 探讨早产儿血清甲状腺激素（ Ｔ３ 、Ｔ４） 水平与胎龄、出生体重的关系。 方法 用放免法测定早产儿血清Ｔ３、Ｔ４、ＴＳＨ 水平，分别按胎龄和体重进行分组比较及相关分析，并对极低体重儿的Ｔ３ 、Ｔ４ 和ＴＳＨ进行了动态观察。 结果 胎龄小于３３ 周或出生体重低于２ ０００ｇ 的早产儿，血清Ｔ３、Ｔ４ 水平显著低于胎龄３４ 周以上或体重大于２ ５００ｇ 者，而ＴＳＨ 在各胎龄或体重组间无显著差别，Ｔ３、Ｔ４ 与胎龄和体重均呈显著正相关，极低体重儿出生后第５ 周Ｔ４ 仍低于相当于纠正胎龄儿的水平。 结论 早产儿血清甲状腺激素水平与胎龄及出生体重呈显著正相关。

Objective To investigate relationship of thyroid hormones (T 3,T 4) to gestational age and birth weight in preterm infants. Methods T 3,T 4 and TSH were measured by radioimmunoassay in 44 preterm infants.The results were compared in groups of different gestational age and birth weight.T 3,T 4 and TSH in very low birth weight infants were followed until 5 weeks after birth. Results T 3,T 4 was lower in preterm infants of less than 33 weeks gestational age(or weighing lower than 2 000g)than in those of elder(or weighter than 2 500g).But there was no significant difference in TSH.T 4 was lower in very low weight preterm infants even at 5 weeks after birth. Conclusion There were significant relation beteween T 3,T 4 and gestational age or birth weight in preterm infants.Thyroxine supplementation may be neccessary for very low birth weight infants.