嗜酸性细胞化生与桥本氏甲状腺炎癌变关系的初步研究

Relationship of eosinophil cells metaplasia with Hashimotos thyroiditis canceration

目的:研究桥本氏甲状腺炎嗜酸性化生细胞中COX-2和Bcl-2表达与癌变的关系。方法:用免疫组织化学方法检测120例桥本氏甲状腺炎组织中嗜酸性化生细胞COX-2和Bcl-2的表达,将其中23例5年内癌变的桥本氏甲状腺炎病例与剩下的97例未癌变的桥本氏甲状腺炎病例中,嗜酸性化生细胞的COX-2和Bcl-2的表达比较,分析嗜酸性化生细胞与桥本氏甲状腺炎癌变风险的关系。结果:COX-2和Bcl-2几乎在所有的桥本氏甲状腺炎嗜酸性化生细胞中均有表达,但表达强弱不一;在5年内癌变的桥本氏甲状腺炎病例中,嗜酸性化生细胞的数量和COX-2和Bcl-2的表达明显高于未癌变病例,差异有统计学意义,P<0.05。结论:桥本氏甲状腺炎中嗜酸性化生细胞的数量以及COX-2和Bcl-2的表达程度与癌变有密切关系。

OBJECTIVE：To study the expressions and significance of COX-2 and Bcl-2 in Hashimotos thyroiditis eosinophil cells. METHODS： The expressions of COX-2 and Bcl-2 were detected in 120 examples of Hashimotos thyroiditis eosinophil cells with immunohistochemistry, the expressions in 23 examples of canceration Hashimotos thyroiditis were compared with the others, and the relationship between the expressions of COX-2 and Bcl-2 in eosinophil cells and the risk of Hashimotos thyroiditis canceration was analyzed. RESULTS： The expressions of COX-2 and Bcl-2 almost existed in all Hashimotos thyroiditis, but there were different expression levels. The expression levels of COX-2 and Bcl-2 in the canceration examples were more obviously strong than those in the no canceration examples, and there was a significant difference （P0.05）. CONCLUSION：There is an intimate relation ship between the risk of canceration together with the quantity of eosinophil cells and the expression levels of COX-2 and Bcl-2 in Hashimotos thyroiditis.