头颈部滤泡树突状细胞肉瘤一例报告并文献复习

Case report of FDCS of head and neck literature review

探讨头颈部滤泡树突细胞肉瘤的临床病理特征及诊断、治疗方法。报道1例复发的右侧颈部滤泡树突细胞肉瘤41岁女性患者的临床资料。应用MEDLINE,以"树突细胞,肉瘤,滤泡状树突细胞"为主题词进行检索。对1986-01-2009-08发生于头颈部的滤泡树突细胞肉瘤并且有英文全文的文章进行分析总结。结果显示,成功手术切除右侧颈部复发的滤泡树突细胞肉瘤,术后予以放疗。通过MEDLINE检索共报道79例头颈部的FDCS患者,50.6%患者进行手术治疗,47.5%复发。21.5%患者进行了术后放疗,复发率35.3%。51.9%的患者复发后再手术和(或)放疗。CD21(+)和CD35(+)对淋巴滤泡树突细胞肉瘤的诊断有重要的意义。初步研究结果提示,淋巴滤泡树突细胞肉瘤是一种少见具有一定恶性倾向的肿瘤。外科手术加放疗是一种较好的治疗方法。

The objective of this study was to study the clinical features, histologic, and cytologic appearance of FDCS （follicular dendritic cell sarcoma） of the head and neck to increase recognition of this rare neoplasm. A patient with follicular dendritic cell sarcoma （FDCS） was presented. A MEDLINE literature search was performed and the literature was reviewed with ＂dendritic cell, sarcoma and follicular dendritic cell＂ as hey from 01-1986 to 08-2009. Results： a large recurred FDCS of the right neck in a 41 years old women was excised and the postoperative irradiation was given. Immunohistochemical staining of CD21（＋） and CD35（＋） were helpful to the diagnosis of FDCS. Totally 79 cases were reported on FDCS of the head and/or neck. Most patients were treated with surgery （50.6%） and 47.5% of them relapsed. Totally 21.5% patients received adjuvant postoperative radiotherapy with recurrence rate of 35.3%. And 51.9% recurred patients received re surgery and/or radiotherapy. In conclusions, FDCS is a rare tumor with an aggressive entity. Surgical resection and postoperative radiotherapy are better treatment modality.