左、右心功能不全患者氨基末端B型利钠肽前体水平的比较

Comparison of NT-proBNP levels between patients with left or right ventricular dysfunction

目的观察左、右心功能不全患者的血浆氨基末端B型利钠肽(脑钠肽)前体(NT-proBNP)水平的差异,探讨NT-proBNP在左、右心功能不全诊断中的应用价值。方法选取96例患者分为4组:左心收缩功能不全组31例,左心舒张功能不全组31例,右心功能不全组14例及20例心功能正常组,用ANALYTICSE170光电免疫发光仪测定血浆NT-proBNP含量,对左、右心功能不全患者的NT-proBNP含量进行比较。结果 4组间比较,以左室收缩功能不全组中NT-proBNP水平(2743±2277)ng/L最高,其次为左室舒张功能不全组(447±416)ng/L,而右室功能不全组NT-proBNP水平(387±333)ng/L较低,但均高于对照组(98±84)ng/L,各组间差异有统计学意义(P=0.000)。结论左心功能不全患者NT-proBNP水平明显高于右心功能不全患者,左室收缩功能不全患者NT-proBNP水平明显较左室舒张功能不全患者高。

Objective To compare N-terminal pro-brain natriuretic peptide （NT-proBNP） levels between patients with left or right ventricular dysfunction and to study the clinical significance of NT-proBNP in left and right ventricular dysfunction. Methods A total of 96 subjects were divided into four groups： the left ventricular systolic dysfunction group （n=31）,the left ventricular diastolic dysfunction group （n=31）,the right ventricular dysfunction group （n=14）,and the normal control group （n=20）. Plasma NT-proBNP concentration was measured by ANALYTICS E170 Immunity Analyzer and compared between left or right ventricular dysfunction patients. Results In the left ventricular systolic dysfunction group,the left ventricular diastolic dysfuncton group and the right ventricular dysfunction group,the concentrations of NT-proBNP were much higher than that in control group （98±84） ng/L,P=0.000. The concentration of NT-proBNP was the highest in the left ventricular systolic dysfunction group （2743±2277） ng/L,followed by the left ventricular diastolic dysfunction group （447±416） ng/L and the right ventricular dysfunction group （387±333） ng/L sequentially. Conclusion The concentration of NT-proBNP is much higher in patients with left ventricular dysfunction than in patients with right ventricular dysfunction,and higher in patients with left ventricular systolic dysfunction than in patients with left ventricular diastolic dysfunction.