肿瘤血管靶向治疗策略的新进展

Recent advances in research of vascular targeting strategy for tumor therapy

肿瘤血管生成(tumor angiogenesis)对大多数实体瘤的生长和转移具有重要意义,他是一个多步骤多因素参与的复杂病理过程.抗肿瘤血管的治疗策略分为抑制肿瘤新生血管生成和阻断肿瘤血管血流两方面.抑制肿瘤新生血管生成旨在抑制肿瘤新生血管生成的过程,目前研究的成果比较多;而阻断肿瘤血管血流则是通过快速而选择性地破坏肿瘤血管功能,使肿瘤血供受阻,对于治疗较大体积的肿瘤有显著的疗效.肿瘤血管的靶向治疗特别是阻断肿瘤血管血流将成为恶性肿瘤的一种新的、重要的常规治疗手段.本文对近年来这两方面的研究进展进行综述.

Tumor angiogenesis is a complicated pathologic process and plays an important role in the growth and metastasis of many solid tumors.There are two vascular targeting strategies for tumor therapy：inhibition of tumor angiogenesis and blockage of tumor blood flow.The former aims to inhibit tumor neovascularization,while the latter seeks to induce a rapid and selective tumor vascular shutdown so that the blood flow to tumors,especially large tumors,is arrested.Vascular targeting therapy is a potential new and important mean of treatment for malignant tumors.In this paper,we summarize the recent advances in research of vascular targeting strategy for tumor therapy.