普萘洛尔治疗婴儿重症血管瘤的疗效及不良反应

Efficacy and adverse effects of propranolol in the treatment of severe hemangiomas in infancy

血管瘤是最常见的婴儿良性肿瘤,重症血管瘤会引起严重的并发症,导致毁容、功能损害甚至危及生命.已有报道普萘洛尔（心得安）治疗重症血管瘤取得较好的疗效.普萘洛尔治疗血管瘤的机制包括收缩血管、抑制血管生成因子如血管内皮生长因子和碱性成纤维细胞生长因子表达,以及促进细胞凋亡.普萘洛尔作为一种非选择性的β-受体阻断剂,服用后可能引起低血压、心动过缓、低血糖、支气管痉挛等不良反应.因此服用时要严密监测生命体征.

Hemangiomas are the most common benign tumor in infancy. Despite of their self-limited course, severe hemangiomas can be accompanied by severe edmplications, which may cause disfigurement,functional impairment, and even life-threatening condition. It has been reported that propranolol has a satisfactory efficacy in the treatment of severe hemangiomaa. The proposed treatment mechanisms of propranolol in hemangiomas include induction of vasoconstriction and apoptosis as well as inhibition of the production of vascular growth factors such aa endothelial vascular growth factor and basic fibroblast growth factors. As a non-selective beta-blocker, propranolol may cause hypotension, bradycardia, hypoglycemia and bronchospasm, so, vital signs should be monitored in patients treated with this drug.