摘要
痤疮丙酸杆菌的结构、分布和生理特点决定其在痤疮发病中的重要作用,尤其与痤疮的炎症损害及严重程度密切有关.目前,针对痤疮丙酸杆菌的痤疮治疗方法众多,包括应用四环素类、克林霉素、红霉素等治疗和过氧苯甲酰或5-氨基酮戊酸光动力疗法等.由于耐药性痤疮丙酸杆菌的出现,抗生素与非抗生素类药物的联合疗法已被证明为最佳治疗手段.痤疮丙酸杆菌全部基因组序列的测定使针对痤疮的菌苗疗法成为可能.
Propionibacterium acnes plays an essential role in the pathogenesis of acne, and is closely associated with the inflammation in and severity of acne, which may be attributed to the structure, colonization and physiological features of this pathogen. Now, many P. acnes-targeted strategies have been developed to treat acne, including antibiotic regimens such as tetracycline, clindamycin, erythromycin, nonantibiotic regimens such as benzoyl peroxide and photodynamic therapy with ALA. With the emergence of antibiotic-resistant P. acnes, the combination of antibiotic and non-antibiotic drugs has proved to be the optimized treatment for acne. The revealment of complete genome sequence of P. acnes has made it possible to treat acne with vaccines targeting P. acnes.
出处
《国际皮肤性病学杂志》
2010年第6期337-340,共4页
International Journal of Dermatology and Venereology
关键词
痤疮
寻常
丙酸杆菌
痤疮
治疗
Acne, vulgaris
Propionibacterium acnes
Therapy
