摘要
水通道蛋白是细胞膜上参与跨膜水转运的一组通道蛋白.水通道蛋白3是人类皮肤中表达量最丰富的水通道蛋白亚型,除对水分子通透外还对甘油等溶质具有通透性.动物研究显示,水通道蛋白3基因敲除后皮肤保湿功能和弹性降低,创伤愈合延缓;水通道蛋白3还与细胞增殖及迁移有关,可能参与皮肤肿瘤的发生、发展和转移.水通道蛋白3与炎症性皮肤病如新生儿中毒性红斑、特应性皮炎等的病理机制相关.维A酸、肿瘤坏死因子-α等多种物质可调节水通道蛋白3的表达,对其表达进行调控将为治疗相关皮肤病带来新的手段.
Aquaporins （AQPs） are a group of membrane transport proteins involved in the transport ofwater across cell membranes. AQP3, the most abundant aquaporin subset in human skin, is permeable notonly to water but also to small solutes such as glycerol. It has been reported that AQP3-knockout mice havereduced stratum corneum water content, elasticity and impaired wound healing. AQP3 has been revealed to berelated to cell proliferation and migration, and involved in the initiation, progression and metastasis of tumors.In addition, AQP3 expression is associated with the pathogenesis of inflammatory cutaneous diseases such asatopic dermatitis and erythema toxicum neonatorum. AQP3 expression can be modulated by multiple factorssuch as retinoic acid and tumor necrosis factor α, and this modulation may provide a new clue for the therapyof related skin diseases.
出处
《国际皮肤性病学杂志》
2010年第6期340-343,共4页
International Journal of Dermatology and Venereology
基金
中华医学会-宝洁美尚科技研究基金
