博莱霉素治疗恶性胸腔积液的临床研究

Intracavitary Bleomycin in the Management of Malignant Pleural Effusions

目的评价博莱霉素治疗恶性胸腔积液的作用和毒性。方法３０例恶性胸腔积液患者应用博莱霉素胸腔内给药治疗。结果有效率７６．７％（２３／３０），完全缓解率５０％（１５／３０）。不良反应有发热、恶心呕吐和胸痛，但少见。结论博莱霉素治疗恶性胸腔积液疗效肯定。并用全身化疗，多次给药可提高疗效，毒副反应轻微。

To evaluated the efficacy of intracavitary bleomycin in the malignant pleural effusions.Thirty patients with malignant pleural effusions were treated with intracavitary bleomycin.The overallresponse rate was 76.7% (23/30),complete response 50%(15/30).Side effects were infrequent with fever、nausea、vomiting and chest pain.This study shows that intracavitary bleomycin was effective to control of the malignant pleural effusions.