鼠伤寒沙门菌L型变异对噬菌体敏感性的影响

Effect on phage sensitivity resulting from the Lformsvariation of Salmonella typhimurium

目的：探讨鼠伤寒沙门菌的Ｌ型变异对噬菌体敏感性的影响。方法：用１２株鼠伤寒沙门菌分型噬菌体对３株体外诱导的鼠伤寒沙门菌Ｌ型及其原菌做噬菌体敏感性检测。结果：裂解原菌的噬菌体大多不能裂解其Ｌ型菌，只有少数噬菌体能同时裂解原菌及其Ｌ型菌。结论：鼠伤寒沙门菌的Ｌ型变异可引起噬菌体受体的丢失，从而导致对相应的噬菌体不再敏感。

Objective: To investigated the effect on phage sensitivity resulting from the Lforms variation of Salmonella typhimurium. Methods: Phage sensitivity of 3 strains of Salmonella typhimurium Lforms induced in vitro and their parents were tested by 12 strains of typing bacteriophages of Salmonella typhimurium. Results: Most bacteriophages which could lysis the parental Salmonella typhimurium could not lysis their Lforms.Only few bacteriophages could lysis both the Lforms and their parents.HX]Conclusion: The Lforms variation of Salmonella typhimuium could induce the loss of bacteriophage receptors,consequently the Lforms were resistant to the parental bacteriophages.