摘要
目的:探讨急性髓性白血病(AML)骨髓细胞动力学的变化。方法:免疫组化ABC法。结果:正常组、初发AML、完全缓解AML及未缓解AML组,其增殖细胞核抗原(PCNA)表达率分别为:123±26、328±76、146±44、274±58正常组和初发AML及未缓解AML组相比较,P<001,存在明显差异,与完全缓解组无显著差别。缓解组与未缓解组也存在有一定差别。结论:①AML完全缓解与未缓解其细胞增殖活性不同。②在骨髓涂片上研究PCNA表达,方法简单,结果肯定,对了解骨髓细胞动力学的变化,有较高的临床价值,对指导AML治疗有一定意义。
Objective: To probe into the changing of bone marrow cell kinetic in AML. Methods: Using immunohistochemical ABC methods. Results: The PCNA experession rates of the normal,the initial,the complete remession and the irremession AML are respectively 12.32.6,32.87.6,14.64.4,27.45.8 and among them exists significant difference. Conclusion: Proliferating cell activete exists difference in the complete remession and the irremession.The process of studying PCNA expression on bone marrow plate is simple with obvious results.so it concluaes high clinic value and enlight the AML treatment.
出处
《河南医学研究》
CAS
1999年第2期147-148,共2页
Henan Medical Research
关键词
急性
髓性
白血病
增殖细胞核抗原
acute
myeloid
leukemia
proliferating cell nuclear antigen