门冬氨酸洛美沙星与头孢西丁治疗社区获得性下呼吸道感染的对照研究

A comparative study of aspartic acid lomefloxacin and cefoxitin in treatment of lower respiratory tract infections

目的探讨洛美沙星与头孢西丁在治疗轻中度社区获得性下呼吸道感染的疗效对比。方法选择2006年1月～2010年4月笔者所在医院诊断为社区获得性下呼吸道感染的住院患者115例进行研究，随机分为头孢西丁组和洛美沙星组，观察两组疗效和安全性。结果头孢西丁组总有效率77．2％，洛美沙星组总有效率82．8％，两组比较差异无统计学意义（P〉0．05）。两组在临床症状的改善方面差异无统计学意义（P〉0．05）。头孢西丁组细菌清除率为85．7％，洛美沙星组为92．6％，两组比较差异无统计学意义（P〉0．05）。结论洛美沙星与头孢西丁在治疗轻中度社区获得性肺炎的疗效相似。

Objective To investigate the effect of aspartic acid lomefloxacin and cefoxitin in treatment of lower respiratory tract infections. Methods From Jan 2006 to Apr 2010,115 patients with lower respiratory tract infections were randomly divided into lomefloxacin group and cefoxitin group. The therapeutic effects and safety were observed. Results There were no significant differences （P 〉 0.05） in the rates of total efficiancy, bacteria clearance and improvement of clinical symptom between two groups. Conclusion The effect of lomefloxacin and cefoxitin in treatment of lower respiratory tract infection is similar.