精氨酸联合纳洛酮治疗肝性脑病合并碱中毒33例

Effect of Arginine and Naloxone in treating 33 cases of patients with hepatic encephalopathy and alkalosis

目的观察精氨酸联合纳洛酮治疗肝性脑病合并碱中毒的疗效。方法肝性脑病患者33例,均有不同程度的碱中毒。治疗前后测定患者血氨的含量,并观察精氨酸联合纳洛酮对肝性脑病的疗效。结果肝性脑病合并碱中毒患者血氨含量明显增加,且与肝性脑病程度相关。精氨酸联合纳洛酮治疗后血氨含量下降程度较为明显,治疗前后相比具有显著性差异(P<0.01)。此外,精氨酸联合纳洛酮治疗患者清醒率达81.82%,效果良好。结论精氨酸联合纳洛酮对肝性脑病合并碱中毒具有明显疗效。

Objective To investigate the therapeutic effects of Arginine and Naloxone on patients with hepatic encephalopathy and alkalosis.Methods 33 patients with hepatic encephalopathy and alkalosis were treated with Arginine and Naloxone.Serum levels of NH3 was examined in all patients before and after treatment.The clinical efficacy was also observed.Results Serum levels of NH3 increased markedly in patients with hepatic encephalopathy and it was correlated with the severity of HE.Serum levels of NH3 decreased after treatment with Arginine and Naloxone.Conclusion Arginine and Naloxone are beneficial agents in treatment of patients with hepatic encephalopathy and alkalosis.