期刊文献+

人类白细胞抗原-B27检测在临床诊断强直性脊柱炎中的应用价值 被引量:10

下载PDF
导出
摘要 目的通过临床资料探讨人类白细胞(HLA)抗原-B27检测在强直性脊柱炎(AS)临床诊断中的应用价值。方法用ELISA法对临床确诊96例AS患者、230例疑似AS患者和200例健康体检者进行HLA-B27抗原检测。结果确诊AS组、疑似AS组和健康对照组HLA-B27阳性率分别为90.6%、45.7%和5.5%,确诊AS组、疑似AS组HLA-B27阳性率明显高于健康对照组(P<0.01),确诊AS组的HLA-B27阳性率明显高于疑似AS组(P<0.01)。结论 HLA-B27抗原与AS疾病密切相关,检测HLA-B27抗原对早期诊断AS有重要意义。
作者 孙芳
出处 《国际检验医学杂志》 CAS 2010年第11期1301-1302,共2页 International Journal of Laboratory Medicine
  • 相关文献

参考文献6

二级参考文献10

  • 1褚洪涛,张百安.云克与松梅乐治疗强直性脊柱炎疗效对比观察[J].中国误诊学杂志,2004,4(3):418-419. 被引量:19
  • 2Liu Y, Li J, Chen B, et al. Familial aggregation of ankylosing spondylitis in Southern China[J]. J Rheumatol, 2001, 28 (3) : 550-553.
  • 3Lingenfelter B, Fuller TC, Hartung L, et al. HLA-B27 screening by flow cytometry[J]. Cytometry, 1995, 22(2) : 146-149.
  • 4Chou CT, Tsai YF, Liu J, et al. The detection of the HLA-B27 antigen by irnmunomagnetic separation and enzyme-linked immunosorbent assay: comparison with a flow cytometric procedure [J]. J Immunol Methods, 2001, 255(1-2):15-22.
  • 5Liu SQ, Yu HC, Gong YZ, et al. Quantitative measurement of HLA-B27 mRNA in patients with ankylosing spondylitis-correlation with clinical aetivity[J]. J Rheumatol, 2006, 33 (6) : 1128-1132.
  • 6Bowness P. HLA B27 in health and disease:a double-edged sword[J].Rheumatology, 2002, 41(8) :857-868.
  • 7Neumtiller J, Schwartz DW, Dauber E,et al. Evaluation of four monoclonal antibodies against HLA-B27 for their reliability in HLA-B27 typing with flow cytometry (FC):comparison with the classic microlymphocytotoxic test (MLCT) [ J ]. Cytometry, 1996, 26(3) :209-215.
  • 8Brown MA, Kennedy LG, MacGregor A J, et al. Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment [J]. Arthritis Rheum, 1997, 40(10): 1823-1828.
  • 9曾庆馀.强直性脊柱炎的诊断[J].中国新药与临床杂志,1999,18(6):381-382. 被引量:6
  • 10郭嘉隆,刘锋.HLA分子与血清阴性脊柱关节病[J].中国社区医师,2002,18(9):12-14. 被引量:12

共引文献40

同被引文献70

引证文献10

二级引证文献40

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部