摘要
目的:观察来曲唑联合唑来磷酸治疗乳腺癌骨转移的临床疗效及不良反应。方法:使用来曲唑联合唑来磷酸静脉注射治疗32例绝经后妇女乳腺癌骨转移伴有不同程度骨痛患者,观察其镇痛效果、骨转移灶的变化及不良反应。结果:32例患者接受治疗后,止痛的总有效率93.75%;骨转移灶有明显缩小,临床获益率90.62%;所有患者均未发现严重的不良反应。结论:来曲唑联合唑来磷酸对绝经后妇女乳腺癌骨转移骨痛的临床止痛疗效明显,对乳腺癌骨转移是一种有效的治疗方法。
Objective： To evaluate the efficacy and adverse effect of Letrozole combined with Zoledronic acid in patients with breast cancer osseous metastasis. Methods ： Thirty-two postmenopausal breast cancer patients with osseous metastasis who got the bone ache were treated with Letrozole and zoledronic acid. The efficacy and adverse effects were analyzed. Results： The total effective rate was 93, 75%. No patient had severe adverse effect. Conclusion： Letrozole combined with zoledronic acid is effective to treat bone ache. It is an effective treatment for breast cancer with osseous metastasis.
出处
《肿瘤预防与治疗》
2010年第2期143-144,152,共3页
Journal of Cancer Control And Treatment
关键词
乳腺癌
来曲唑
唑来磷酸
骨转移
Breast Cancer
Letrozole
Zoledronic Acid
Osseous Metastasis
