PPARγ在子宫颈癌和子宫颈上皮内瘤样变中的表达及意义

Expression and Significance of PPARγ in Cervical Intraepithelial Neoplasia and Cervical Carcinoma

目的:探讨过氧化物酶增殖物激活受体γ(PPARγ)在子宫颈癌和子宫颈上皮内瘤样变中的表达及其临床意义。方法:应用免疫组化法检测31例子宫颈癌、18例子宫颈上皮内瘤样变和10例正常子宫颈组织石蜡包埋组织中PPARγ的表达。结果:PPARγ在子宫颈癌中的阳性表达率为80.7%,在CIN中的阳性表达率为50.0%,在正常子宫颈组织中的表达率为10.0%。三者比较差异具有统计学意义(P<0.01)。PPARγ高表达与宫颈癌患者的年龄、临床分期、分化程度和组织学类型均无相关性(P>0.05)。结论:PPARγ在宫颈癌中的表达高于宫颈上皮内瘤变和正常宫颈组织,PPARγ高表达与宫颈癌的发生有关。

Objective： To investigate the expression of PPART in cervical carcinoma and cervical intraepithelial neoplasia, and to evaluate the possible significance in cervical carcinoma. Methods： Immunohistochemistry method was used to detect PPARγ expression in 31 cases of cervical carcinoma ,18 cases of cervical intraepithelial neoplasia and 10 cases with normal cervical issue. Results： The positive rates of PPARγ was 80. 7% in cervical carcinoma, 50. 0% in CIN and 10. 0% in normal cervix respectively（P 〈0. 01 ）. The clinicopathological analysis of patients showed that the increase of PPAR＇y expression was not associated with age, clinical stages, differentiation grades and histological classification. Conclusion： The expression of PPAR-γ is higher in cervical carcinoma than in cervical intraepithelial neoplasia and normal issue , which may be used as useful biomarkers.