摘要
目的:探讨静脉全麻对脑胶质细胞瘤开颅手术患者白细胞介素-2(IL-2)和可溶性白细胞介素-2受体(sIL-2R)的影响意义。方法:选择天坛医院神经外科择期脑胶质细胞瘤开颅切除术患者21例。检测麻醉前,麻醉诱导后,手术结束时,术后2h的血清IL-2及sIL-2R浓度。结果:IL-2浓度在麻醉诱导后、手术结束时和术后2h均较麻醉前明显降低(P<0.05)。麻醉诱导后sIL-2R浓度较麻醉前有所升高,但差异无统计学意义(P>0.05),手术结束时和术后2h的sIL-2R浓度明显低于麻醉前(P<0.05)。结论:静脉麻醉与手术对脑胶质细胞瘤患者免疫功能有抑制作用。
Objective： To investigate the influence of total intravenous general anesthesia on serum interleukin-2 （IL-2） and soluble interleukin-2 receptor （slL-2R） in patients with cerebral glioma craniotomy. Methods： In twenty-one cerebral glioma craniotomy patients, serum IL-2 and slL-2R were measured before anesthesia, after induction of anesthesia, at the end of operation, and at the 2h after operation. Results： Serum IL-2 concentration decreased significantly after induction of anesthesia, at the end of operation and at the 2h after operation comparing with the IL-2 level before anesthesia（ P 〈0.05 ）. Serum slL-2R coneentration after induction of anesthesia increased little than that before anesthesia（ P 〉 0.05 ）. Serum slL-2R concentration at the end of operation and 2h after operation decreased significantly than that before anesthesia（ P 〈 0.05 ）. Conclusion： Total intravenous general anesthesia and operation inhibited immune functions of patients with cerebral glioma.
出处
《肿瘤预防与治疗》
2010年第3期214-215,227,共3页
Journal of Cancer Control And Treatment
基金
天坛医院青年科研基金(2008-03)
