普贝生用于足月引产的效果观察

目的观察普贝生促宫颈成熟的疗效与安全性。方法采用随机、双盲对照的方法将240例妊娠孕妇随机分为两组。试验组120例以阴道放置普贝生促宫颈成熟,对照组120例用小剂量缩宫素促宫颈成熟。比较两组孕妇的宫颈Bishop评分、分娩情况及对胎儿、新生儿的影响。结果两组治疗后宫颈Bishop评分均有所提高,但治疗组较对照组增高更为显著,两组比较差异有极显著性(P<0.001)。实验组阴道分娩率为79.2%,明显高于对照组的阴道分娩率(43.3%),差异具有非常显著性(P<0.01)。两组胎儿窘迫、产后出血量及新生儿Apgar评分差异无显著性(P>0.05)。结论普贝生用于足月促宫颈成熟安全、有效,值得临床借鉴。

Objective To observe prostaglandin E2 suppositoriesi cervical ripening effect of health and safety.Methods A randomized,double-blind method of 240 pregnant women were randomly divided into two groups of pregnant women.Experimental group of 120 patients with vaginal Pubei cervical ripening Health.Control group,120 cases of low-dose oxytocin for cervical ripening.Comparison of cervical Bishop score two pregnant women,childbirth and the fetus,newborn.Results After treatment,cervical Bishop score were improved,but the treatment group than in the control group increased even more signifi cant,difference between the two groups was signifi cant（P〈0.001）.Experimental group,79.2% vaginal delivery rate was signifi cantly higher than that of vaginal delivery rate（43.3%）,the difference was signifi cant（P〈0.01）.Conclusion Prostaglandin E2 suppositoriesi for cervical ripening at term is safe and effective,it is the clinical reference