摘要
目的 评价表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI)对局部晚期或转移性非小细胞肺癌(NSCLC)患者临床疗效与安全性.方法 对经病理确诊的初治或经治的29例晚期NSCLC的患者,予吉非替尼250mg/d或厄洛替尼150mg/d 口服,至肿瘤进展或发生不可耐受的毒副作用.结果 29例患者的总有效率为48.3%,疾病控制率为72.4%,中位疾病进展时间为7.7个月;随访结束时11例患者死亡,死亡患者的中位生存期为8个月;主要的的毒副作用是皮疹和腹泻,均可耐受.结论 EGFR-TKI制剂治疗NSCLC,具有较好的疗效和耐受性.
Objective Gefitinib and erlotinib are small molecule tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKI). EGFR-TKI is a valid treatment for advanced non-small-cell lung cancer (NSCLC). Increased likelihood of responding to small-molecule therapy is associated with Asian race, female gender, never smoking and adenocarcinoma. To evaluate the clinical efficacy and toterability of EGFR-TKI in locally advanced or metastatic NSCLC patients. Methods Twenty-nine pathologically verified, locally advanced or metastatic NSCLC patients were treated with gefitinib 250 mg/d or erlotinib 150mg/d, until disease progression or unacceptable toxicity. Results Overall response rate (RR) of 29 patients was 48.3%, and the disease control rate (DCR) was 72.4%. The median progession-free survival (PFS) was 7.7 month. At the end of follow-up, eleven patients died of lung cancer. The median overall survival of these dead patients was 8 months. The most common drug-related adverse events were skin rashes and diarrhea, but generally mild and tolerant. Conclusion EGFR-TKI is effective and safe in the treatment of patients with locally advanced or metastatic NSCLC
出处
《浙江医学》
CAS
2010年第7期1028-1030,共3页
Zhejiang Medical Journal