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内脏脂肪素与胰岛素抵抗的研究进展 被引量：2

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摘要 内脏脂肪素（Visfatin）主要是由内脏脂肪组织表达的一种脂肪细胞因子，可参与胰岛素抵抗的发生与发展过程。现笔者将近年来关于Visfatin的来源、作用、调节和与炎症、胰岛素抵抗间的关系及其机制方面的最新研究进展作一综述。
作者 宁帆 谷卫
机构地区 浙江大学医学院附属第二医院内分泌科 嘉善县第一医院内分泌科工作
出处 《浙江医学》 CAS 2010年第7期1122-1125,共4页 Zhejiang Medical Journal
关键词 胰岛素抵抗 内脏脂肪素 脂肪细胞因子 脂肪组织表达
分类号 R587.1 [医药卫生—内分泌]
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参考文献4

二级参考文献32

  • 1Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin : a protein secreted by visceral fat that mimics the effects of insulin [ J ]. Science, 2005,307 ( 5708 ) :426-430.
  • 2Chen M P, Chung FM, ChangD M, et al. Elevated plasma level of Visfatin pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus[ J]. J Clin Endocrinol Metab,2006,91 ( 1 ) :295- 299.
  • 3Sethi JK , Vidal - Puig A . Visfatin : the missing link between intra-abdominal obesity and diates? [ J]. Trends Mol Med, 2005, 11(8) :344-347.
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  • 6Klotlng N , Kloting I . Visfatin : gene expression in isolated adipo-eytes and sequence ailalysis in obese WOKW rats compared with lean control rats [ J ]. Biochem Biophys Res Commun, 2005, 332 (4) :1070-1072.
  • 7Frdelund-Larsen L, Akerstrom T, Nielsen S, et al. Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise[ J]. Am Physiol Endocrinol Metab, 2007,292 ( 1) : E24- E31.
  • 8Bemdt J, KlotingN, Kralisch S,et al. Plasma Visfatin concentrations and fat depot-specific mRNA expression in humans[ J ]. Diabetes, 2005,54 (10) :2911-2916.
  • 9Kralisch S, Klein J, Lossner U, et al. Hormonal regulation of the novel adipocytokine Visfatin in 3T3-L1 adipocytes[ J ]. J Ertdocrinol, 20(15,185(3) :RI-R8.
  • 10Amer P. Visfatin-a true or false trail to type 2 diabets mellitus [ J]. J Clin Endocrinol Metab ,2006,91 ( 1 ) :28-30.

共引文献45

同被引文献39

  • 1杨义生,陈家伦.脂肪组织分泌功能研究新进展[J].中国糖尿病杂志,2004,12(3):228-230. 被引量：14
  • 2广东省糖尿病流行病学调查协作组.腰围/身高比值:预测糖尿病和高血压的有效的腹型肥胖指标[J].中华内分泌代谢杂志,2004,20(3):272-275. 被引量：160
  • 3曹东红,谭卫强.胰岛素抵抗与妊娠期糖尿病[J].内科,2007,2(1):109-111. 被引量：25
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  • 6Romero-Corral A, Montorl VM, Somers VK, et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies [J]. The Lancet,2006,368:666-678.
  • 7Ashwell M, Gibson S. Waist to height ratio is a simple and effective obesity screening tool for cardiovascular risk factors: analysis of data from the British National Diet and Nutrition Survey of adults aged 19-64 years[ J ]. Obes Facts,2009,2:97-103.
  • 8Wang ZQ, Si DM, Liu MN. Can a consensus be reached on waist circumference cutoffs by optimizing sensitivity and specificity (J]. Atherosclerosis,2010,213:332-333.
  • 9Schneider H J, Klotsche J, Silber S, et al. Measuring abdominal obesity: effects of height on distribution of cardiometabolic risk factors risk using waist circumference and waist-to-height Ratio [J]. Diabetes Care, 2011,34: 7.
  • 10Goulding A, Taylor RW, Grant AM, et al. Waist-to-height ratios in relation to BMI z-scores in three ethnic groups from a representative sample of New Zealand children aged 5 - 14 years (J). International Journal of Obesity,2010,34:1188-1190.

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浙江医学
2010年 第7期

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