抑癌基因PTEN及其在肿瘤中的突变失活
被引量：3
摘要
正常细胞和肿瘤细胞的蛋白质磷酸化及去磷酸化研究一直引人注目。研究表明，细胞内蛋白质酪氨酸磷酸化水平受蛋白质酪氨酸激酶和蛋白质酪氨酸磷酸酶动态调控。多种癌基因的表达产物具有蛋白质酪氨酸激酶活性并参与肿瘤形成进程，提示蛋白质磷酸酪氨酸磷酸酶可能抑制肿瘤形...
出处
《生命的化学》
CAS
CSCD
1999年第2期95-97,共3页
Chemistry of Life
参考文献4
-
1Wang S I，Clin Cancer Res，1998年，4卷，811页
-
2Li D M，Cancer Res，1997年，57卷，2124页
-
3Li L W，J Biol Chem，1997年，272卷，29403页
-
4Li J，Science，1997年，275卷，1943页
同被引文献14
-
1[2]Steck PA, Pershouse MA, Jasser SA, et al. Indentification of a candidate tumor suppressor gene MMAC1 at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet, 1997,15:356
-
2[3]Lee JO ,Yang H, Georgescu MM, et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell, 1999,99:323
-
3[4]Rizo J, Sudhor TC. C2-domains, structure and function of a universal Ca2+-binging domain. J Biol Chem, 1998,273:15879
-
4[5]Georgescu MM. The tumor suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc Natl Acad Sci USA, 1999,96:10182
-
5[6]Tolkacheva T, Chan AML. Inhibition of H-Ras tansformation by the PTEN/MMAC1/TEP1 tumor suppressor gene. Oncogene, 2000, 19:680
-
6[7]Adey NB, Huang L, Ormonde PA, et al. Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. Cancer Res, 2000, 60:35
-
7[8]Wu X, Dowbenko D, Spencer S, et al. Evidence for regulation of PTEN tumor suppressor by a membrane-localized multi-PDZdomain of MAG13, a novel membrane-associated guanylate kinase. Proc Natl Acad Sci USA, 2000, 97:4233
-
8[9]Wu X. Innteraction of the tumor suppressor PTEN/MMAC. Biol Chem, 2000,275:21477
-
9[10]Cantley LC. New insights into tumor suppression: PTEN suppresses tumor formatoin by restraining the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci USA, 1999, 96:4240
-
10[11]Toker A, Newton AC. Cellular signaling: pivoting around PDK-1. Cell, 2000, 103:185
二级引证文献3
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1任小娟,张少华,图雅,李彦文.中医药治疗恶性肿瘤的研究进展[J].时珍国医国药,2004,15(9):606-607. 被引量：2
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2吕强,唐亮,李建华,宫鹏涛,徐晓芳,田甜,李泽中,雒伟伟,邢沈阳,张西臣,高久春.RNA干扰PTEN基因对HCT-8细胞增殖能力的影响[J].吉林大学学报（医学版）,2011,37(2):231-235. 被引量：3
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3张云鹤,李广太,王红霞.抑癌基因PTEN、p53蛋白在外阴上皮内非瘤变中的表达及相关性研究[J].中国临床医生杂志,2017,45(5):85-89. 被引量：5
