摘要
目的:探询药品不良反应(ADR)发生的特点,以期为临床合理用药提供依据。方法:采取回顾性分析方法,对2006—2009年中山大学附属第六医院医务人员自愿呈报的148份ADR报告中患者的一般情况、可疑药品分类、临床表现、累及器官或系统、因果关系、ADR分类及转归、报告人职业情况等信息进行分析。结果:ADR发生的男女比例为1︰1.08,以≥61岁的老年患者和≤15岁的儿童患者最多,涉及药品15类88种,抗微生物药的构成比最高(44.4%),其中头孢菌素类和氟喹诺酮类引发的ADR最多。ADR的损害以皮肤及其附件损害、全身性损害、中枢外周神经系统损害、消化系统损害为主。ADR报告以医生上报为主(95.3%)。结论:应重视ADR监测工作,不断拓展ADR监测范围,尽量降低漏报率,逐步提高ADR报告质量。
OBJECTIVE：To investigate the features of adverse drug reactions（ADR） in our hospital in order to promote rational drug use.METHODS：By a retrospective analysis,a total of 148 cases of ADR reports collected in our hospital from 2006 to 2009 were analyzed statically in respects of the patients’general situation,the category of the suspected drugs,clinical manifestations,organs or systems involved,causality,categories and outcomes of ADRs and the occupations of reporters etc.RESULTS：The 148 ADR cases occurred mostly in patients aged 61 years or older or 15 years or younger with a male：female ratio of 1：1.08.A total of 88 kinds of drugs in 15 categories were involved,among which antimicrobial drugs took the lead with a percentage of 44.4%,of which,cephalosporins and fluoroquinolones took the lead in terms of ADR incidences.The ADRs manifested chiefly as lesions of skin and its appendants,lesions of central and peripheral nervous system and digestive system or systemic lesion.Doctors represented the largest group（95.3%） as reporters in ADR reports.CONCLUSION：It is urgent to strengthen ADR monitoring,extend the monitoring range of ADR,decrease the ratio of missing report,and improve the quality of ADR reports gradually.
出处
《中国医院用药评价与分析》
2010年第11期1035-1038,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
