卡介菌多糖核酸和核酪治疗小儿哮喘疗效观察

Evaluation of polysaccharide nucleic acid fraction of BCG and point-injection in the treatment of children asthma

目的:观察在常规抗炎、支气管扩张剂等治疗的基础上加用卡介菌多糖核酸注射液及核酪注射液治疗小儿支气管哮喘的临床疗效。方法:将120例哮喘患儿随机分为两组,对照组60例,给予常规抗炎、支气管扩张剂等治疗。治疗组60例在此基础上给予卡介菌多糖核酸及核酪注射液治疗。对两组用药后3个月、6个月的喘息缓解时间和复发症状及体征观察记录并统计分析。结果:治疗组明显显效22例,明显显效率36.7%;显效28例,显效率46.7%;有效8例,有效率13.3%;无效2例,总有效率96.7%。对照组明显显效4例,明显显效率6.7%,显效15例,显效率25%,有效20例,有效率33.3%,无效21例,总有效率65%。两组明显显效率和总有效率有统计学意义(P<0.01,P<0.01)。结论:卡介菌多糖核酸和核酪注射液联合使用治疗儿童哮喘疗效显著,可改善临床症状,提高机体免疫力,缩短疗程,减少哮喘发作,延长哮喘缓解期等,值得临床推广应用。

Objective To study the treatment of children asthma on the basis of conventional therapy combined with polysaccharide nucleic acid fraction of BCG（BCG-psn）and point injection.Method Total 120 patients were separated into two groups,the control group（n=60）was given conventional therapy such as anti-inflammatory and bronchial tube expand medicines,on the basis of conventional therapy,the treatment group（n=60）was given BCG-psn and point injection,the pant relieve time and recurrence of symptoms and sign after 3 and 6 months＇ treatment,the data were analyzed.Results In the treatment group,remarked obvious effects in 22 cases（36.7%）,obvious effects in 28 cases（46.7%）,effective in 8 cases（13.3%）,invalid in 2 cases and the total effective rate was 96.7%.In the control group,remarked obvious effects in 4 cases（6.7%）,obvious effects in 15 cases（25%）,effective in 20 cases（33.3%）,invalid in 21 cases and the total effective rate was 65%.The remarked obvious effects and the total effects rate between the two groups had significant difference（P0.01）.Conclusion BCG-psn and point injection treating children asthma has remarked effects,can improve clinical symptoms,enhance immune,reduce treatment course,reduce asthma on-setting,prolong the relieve time,is worthy of clinical application.