摘要
采用单体型相对风险和传递／不平衡检验方法，在中国人群中对注意缺损多动障碍（ADHD）与DXS7位点进行了遗传关联分析。结果表明，以父母双亲为对照，DXS7位点157bp等位基因与ASHD具有显著关联（χ2=9．10，P＜0.05）并连锁(χ2=953，P＜0.05)．提示，ADHD关联和连锁于DXS7位点。
The present study was designed to assess the genetic association between attention-deficithyperactivity disorder(ADHD) and DXD7 locus polymorphism in Chinese population, with haplotype-based haplotype relative risk(HHRR) and the transmission/ disequilibrium test(TDT) analysis. We foundsignificant association(x2=9.10, P< 0.05) and linkage (x2=9.53, P<0.05) between the 157bp DXS7 alleleand DSM-Ⅲ-R-diagnosed ADHD(N = 54) in trios composed of father, mother and affected offspring.Our results suggest that ADHD was associated and in linkage with DXS7 locus.
出处
《遗传》
CAS
CSCD
北大核心
1999年第2期7-10,共4页
Hereditas（Beijing)
