摘要
硒蛋白含有一种特殊氨基酸——硒代半胱氨酸。在翻译阶段，该氨基酸从硒蛋白ｍＲＮＡ编码区的ＵＧＡ密码子处掺入多肽链。已证明它由丝氨酸和活性硒供体分子合成。一种独特的ｔＲＮＡ、某些特殊蛋白质因子以及硒蛋白ｍＲＮＡ的特殊二级结构是ＵＧＡ解读为硒代半胱氨酸所必需的。
Selenoproteins contain a typical amino acid selenocysteine, which is co translationally incorporated into polypeptide chain at UGA codons in the coding region of selenoprotein mRNA. It was proved that selenocysteine is synthesized from serine and active selenium donor. The decoding of UGA as selenocysteine requires a unique tRNA, some proteins, and special secondary structure in the mRNA.
出处
《生物工程进展》
CSCD
1999年第2期37-40,共4页
Progress in Biotechnology
