期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

SPARC在特发性肺纤维化的研究进展

Research progress of SPARC in idiopathic pulmonary fibrosis
原文传递
导出
摘要 富含半胱氨酸的酸性分泌蛋白为一种多功能糖蛋白,其可通过调节细胞与细胞外基质相互作用、促成纤维细胞增殖分化及调节血管生成等作用影响肺纤维化发生发展过程,在肺纤维化进程中可能起促进作用. Secreted protein acidic and rich in cysteine is a multifunctional glycoprotein. It can influence the development of pulmonary fibrosis by regulating the interactions of cell and extracellular matrix, promoting the proliferation and differentiation of fibroblast,and regulating the angiogenesis. It may play a role in the process of pulmonary fibrosis.
作者 吕晓 郑金旭
机构地区 江苏大学临床医学院 江苏大学附属医院呼吸科
出处 《国际呼吸杂志》 2010年第22期1396-1398,共3页 International Journal of Respiration
关键词 SPARC 肺纤维化 细胞外基质 SPARC Pulmonary fibrosis Extracellular matrix
分类号 R563 [医药卫生—呼吸系统]
  • 相关文献

参考文献24

  • 1特发性肺(间质)纤维化诊断和治疗指南(草案)[J].中华结核和呼吸杂志,2002,25(7):387-389. 被引量：631
  • 2Phan E,Ahluwalia A,Tarnawski AS.Role of SPARC --matricellular protein in pathophysiology and tissue injury healing.Implications for gastritis and gastric ulcers.Med Sci Monit,200 7,13:25-30.
  • 3Brekken RA,Sage EH.SPARC,a matricellular protein:at the crossroads of cell-matrix communication.Matrix Biol,2001,19:816-827.
  • 4Termine JD,Kleinman HK,Whitson SW,et al.Osteonectin,a bone-specific protein linking mineral to collagen.Cell,1981,26:99-105.
  • 5Chun YH,Yamakoshi Y,Kim JW,et al.Porcine SPARC:isolation from dentin,cDNA sequence,and computer model.Eur J Oral Sci,2006,114:78-85.
  • 6Hohenester E,Maurer P,Timpl R.Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40.EMBO J,1997,16:3778-3786.
  • 7Sawhney RS.Expression and regulation of SPARC,fibronectin,and collagen Ⅳ by dexamethasone in lens epithelial cells.Cell Biol Int,2002,26:971-983.
  • 8Francki A,Motamed K,McClure TD,et al.SPARC regulates cell cycle progression in mesangial cells via its inhibition of IGF-dependent signaling.J Cell Biochem,2003,88:802-811.
  • 9邬碧波,张黎明,付莉莉,王文靖,梅长林.富含半胱氨酸酸性分泌糖蛋白及其肽段对人系膜细胞增殖和凋亡的作用[J].中华肾脏病杂志,2006,22(4):215-220. 被引量：3
  • 10Nozaki M,Sakurai E,Raisler BJ,et al.Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A.J Clin Invest,2006,116:422-429.

二级参考文献15

  • 1王文靖,梅长林,孙田美,汤兵,李占园,徐成钢.富含半胱氨酸的酸性分泌糖蛋白对囊肿衬里上皮细胞细胞周期及其调控基因表达的影响[J].中华肾脏病杂志,2005,21(2):108-111. 被引量：3
  • 2王文靖 汤兵 梅长林 等.常染色体显性多囊肾病患者体液富含半胱氨酸的酸性分泌糖蛋白浓度及其在肾组织中的表达[J].中华肾脏病杂志,2004,20:63-67.
  • 3Yan Q,Sage EH.SPARC,a matricellular glycoprotein with important biological functions.J Histochem Cytochem,1999,47:1495-1506.
  • 4Bradshaw AD,Sage EH.SPARC,a matricellular protein that functions in cellular differentiation and tissue response to injury.J Clin Invest,2001,107:1049-1054.
  • 5Francki A,Bradshaw AD,Bassuk JA,et al.SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells.J Biol Chem,1999,274:32145-32152.
  • 6Kupprion C,Motamed K,Sage EH.SPARC (BM-40,osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells.J Biol Chem,1998,273:29635-29640.
  • 7Gary KY,Wood YC,Shu WN,et al.SPARC (Secreted Protein Acidic and Rich in Cysteine) induces apoptosis in ovarian cancer cells.Am J Pathol,2001,159:609-622.
  • 8Francki A,Sage EH.SPARC and the kidney glomerulus:matricellular proteins exhibit diverse functions under normal and pathological conditions.Trends Cardiovasc Med,2001,11:32-37.
  • 9Bradshaw AD,Francki A,Motamed K,et al.Primary mesenchymal cells isolated from SPARC-null animals display accelerated rates of proliferation.Mol Biol Cell,1999,10:1569-1579.
  • 10Sage EH,Funk SE,Steadele M,et al.Cleavage of the matricellular protein SPARC by matrix metalloproteinase 3 produces polypeptides that influence angiogenesis.J Biol Chem,2003,278:37849-37857.

共引文献632

国际呼吸杂志
2010年 第22期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部