POU同源域蛋白的结构及发育中的功能

POU domain Protein Structure and Its Function in Development.

ＰＯＵ同源域蛋白含有两个保守的亚结构域以及它们之间有变化的连接区．两个亚结构域与ＤＮＡ相互作用，在连接区可塑性和辅因子的帮助下，ＰＯＵ蛋白作为调控因子和转录因子，显示出错综复杂的ＤＮＡ结合和识别能力．在脊椎动物和无脊椎动物中，ＰＯＵ蛋白参与胚胎发生的早期过程。

POU domain proteins contain tow high conserved subdomains ( POU H and POU S) and variable linker between them. POU proteins interact with DNA by POU H and POU S. In aid of the domain flexibility and requirement of cofactors, POU proteins exhibit very complicated ability to bind and recognize DNA in function of regulator and transcription factors. In vertebrate and invertebrate, POU proteins take part in early embryogenesis, exert much regulation in cell lineage differentiation and neural development .