Wnt基因与生物发育和肿瘤发生

Wnt Genes in Biological Development and Oncogenesis .

Ｗｎｔ基因所编码的蛋白质与许多生长因子一样具有分泌型生长因子的结构特点；分泌后能与细胞表面基质及其特异性受体Ｆｒｉｚｚｌｅｄ蛋白相互作用，通过其下游的一系列诸如Ｄｓｈ（Ｄｉｓｈｅｖｅｌｅｄ）、β环形蛋白、ＧＳＫ３（ｇｌｙｃｏｇｅｎｓｙｎｔｈａｓｅｋｉｎａｓｅ３）、ＡＰＣ（ａｄｅｎｏｍａｔｏｕｓｐｏｌｙｐｏｓｉｓｃｏｌｉ）等蛋白质的磷酸化与去磷酸化的过程来完成Ｗｎｔ信号的传导。

The Wnt genes belong to an ever expanding family of proto oncogenes that express in species ranging from Drosophila to man. Wnt proteins , as well as other growth factors or signaling molecules, have the characteristics of secreted growth factors. As recently, a group of proteins in Frizzled (Fz) family have been identified as the putative receptors of Wnt family,several components are implicated in the downstream of Wnt/Fz signaling pathway, such as Dishevelled, GSK3 (glycogen synthase kinase 3), APC (adenomatous polyposis coli ) and β catenin.This signal transduction pathway plays a pivotal role not only in the formation and organization of developing organs, but also in biological tumorigenesis.