反义核酸抗肝炎病毒研究进展

The Advance of Antisense Nucleotides Against Hepadnavirus.

病毒性肝炎的治疗一直是困扰人类的一个难题．目前可利用的药物仍屈指可数．反义核酸技术的发展为病毒性肝炎的治疗带来了新的希望．利用反义ＤＮＡ，反义ＲＮＡ和核酶技术来抑制乙型肝炎病毒，丙型肝炎病毒和丁型肝炎病毒，在体外已进行了大量的研究，体内也进行了一些研究。

Therapy of hepadnvirus infection is still one of the most difficult problems for human beings.At present few drug can be used for therapy.Antisense strategies against hepadnviral infections gives a new hope for patients.A lot of study was carried out in vitro , and very good results were shown. Some investigation have been done in vivo . These results demonstrate the potential clinical use of antisense nucleotides for hepadnavirus infection.