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以NMDA受体为靶点治疗慢性疼痛的研究进展 被引量：1

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作者 于英妮 施冲 陆建华
机构地区 徐州医学院 广州军区广州总医院全军临床麻醉中心
出处 《广东医学》 CAS CSCD 北大核心 2010年第22期3001-3002,共2页 Guangdong Medical Journal
基金 广东省自然科学基金面上项目(编号:07000059)
关键词 慢性疼痛 靶点治疗 NMDA受体 分子机制 药物
分类号 R441.1 [医药卫生—诊断学]
  • 相关文献

参考文献15

  • 1JIN C,WOODWARD J J.Effects of 8 different NR1 splice variants on the ethanol inhibition of recombinant NMDA receptors[J].Alcohol Clin Exp Res,2006,30(4):673-679.
  • 2MORGADO VALLE C,FELDMAN J L.NMDA receptors in preBo tzinger complex neurons can drive respiratory rhythm independent of AMPA receptors[J].J Physiol,2007,582(Pt 1):359-368.
  • 3TAI K K,TRUONG D D.NMDA receptor-mediated excitotoxicity contributes to the cerebral hypoxic injury of a rat model of posthypoxic myoclonus[J].Brain Res,2007,1133(1):209-215.
  • 4PELISSIER T,INFANTE C,CONSTANDIL L,et al.Antinociceptive effect and interaction of uncompetitive and competitive NMDA receptor antagonists upon capsaicin and paw pressure testing in normal and monoarthritic rats[J].Pain,2008,134(1/2):113-127.
  • 5KHAN A M,STANLEY B G,BOZZETTI L,et al.N-methyl-D-aspartate receptor subunit NR2B is widely expressed throughout the rat diencephalon:an immunohistochemical study[J].J Comp Neurol,2000,428(3):428-449.
  • 6崔苏扬,赵峰.慢性疼痛治疗进展[J].中国厂矿医学,2007,20(6):577-578. 被引量：3
  • 7李惠萍,韦成全,莫玉兰,熊云新,吴钢,莫宁,裴世成,戴体俊.氯胺酮的镇痛作用与脊髓NMDA受体的关系[J].解放军药学学报,2007,23(4):267-269. 被引量：7
  • 8赵重甲,戴秋云.芋螺镇痛多肽研究进展[J].药学学报,2009,44(6):561-565. 被引量：7
  • 9GLORIOSO J C,FINK D J.Herpes vector-mediated gene transfer in the treatment of chronic pain[J].Mol Ther,2009,17(1):13-18.
  • 10MYERS K J,DEAN N M.Sensible use of antisense:how to use oligonucleotides as research tools[J].Trends Pharmacol Sci,2000,21(1):19-23.

二级参考文献15

共引文献14

同被引文献13

  • 1Hermann C. Psychobiology of pain processing and pain memory in children and adolescents [ C ]. Abstracts of 12th world congress on pain, 2008.
  • 2Kroenke K, Krebs EE, Bair MJ. Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews [ J ]. Gen Hosp Psychiatry, 2009, 31(3): 206-219.
  • 3Wallace JL, Viappiani S, Bolla M. Cyclooxygenase-inhibiting nitric oxide donators for osteoarthritis [ J]. Trends Pharmacol Sci, 2009, 30(3) : 112-117.
  • 4Schmidtko A, Lotsch J, Freynhagen R, et al. Ziconotide for treatment of severe chronic pain [ J]. Lancet, 2010, 375 (9725) : 1569-1577.
  • 5Sloane EM, Soderquist RG, Maier SF, et al. Long-term control of neuropathic pain in a non-viral gene therapy paradigm [J]. Geue Ther, 2009, 16(4) : 470-475.
  • 6Tsuchihara T, Ogata S, Nemoto K, et al. Nonviral retrograde gene transfer of human hepatocyte growth factor improves neuropathic pain-related phenomena in rats [ J]. Mol Ther, 2009, 17 (1) : 42- 50.
  • 7Chiechio S, Zammataro M, Robert W. Targeting Chronic Pain with Epigenetic Drugs: Focus on mGlu2 Receptors Molecular and Cellular [J]. Pharmacology, 2009, 1(4): 194-199.
  • 8Chiechio S, Copani A, Zammataro M, et al. Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatmentsfor chronic pain [ J ]. Trends Pharmacol Sci, 2010, 3l (4) : 153-160.
  • 9Garraway SM, Xu Q, lntorrlsi CE. siRNA-mediated knock-down of the NR 1 subunit gene of the NMDA receptor attenuares [ J]. J Pain, 2009, 10(4) : 380-390.
  • 10Liu XJ, Gingrich JR, Vargas-Caballero M. Treatment of inflammatory and neuropathic pain by uncouphng Src from the NMDA receptor complex [J]. Nat Med, 2008, 14(12): 1325- 1332.

引证文献1

广东医学
2010年 第22期

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