鼻病毒感染与儿童哮喘急性加重机制

Rhinovirus infection and acute exacerbation of asthma in children

人鼻病毒（HRV）感染是哮喘急性发作和（或）加重的重要诱发因素,但其致病机制极其复杂,除鼻病毒的直接作用及因炎性介质释放和炎性细胞浸润而导致机体的炎症反应外,HRV感染诱导机体的异常免疫反应特别是Th1/Th2免疫失衡及调节性T细胞功能异常已受到研究者们的广泛重视.深入研究HRV感染所诱导的儿童哮喘急性发作,对阐明哮喘的发病机制及探索疾病免疫治疗有重要意义.

Human rhinovirus （HRV） infection is an important predisposing factor of acute asthma attacks and exacerbations, but the pathogenic mechanism is extremely complex. Inflammatory responses can be caused by the direct effect of rhinovirus and the release of inflammatory mediators and inflammatory cell infiltration. HRV infection stimulates the body＇s abnormal immune response, especially Thl / Th2 immune imbalance and dysfunction of regulatory T cells has attracted extensive attention. In-depth study in the pathogenic mechanism of acute asthma exacerbation induced by HRV infection in children is essential to elucidate the pathogenesis of asthma and to explore immunotherapy of asthma.