MMP-12与肺部疾病的关系被引量：2

The relationship of MMP-12 and the pulmonary disease

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摘要基质金属蛋白酶-12（MMP-12）是基质金属蛋白酶家族中的一员,是细胞外基质降解的主要介质,结构包括前肽域、催化域和血红素结合蛋白样域.MMP-12的作用主要是基因转录和抑制物的调节两个方面.MMP-12的过度表达导致病理的细胞外基质蛋白降解和过度的气道重塑,引起哮喘、肺气肿等许多呼吸系统疾病. Matrix matalloprotenases-12（MMP-12） is a member of the matrix matalloprotenases family,and it is a main mediator to degradate the extracellular matrix. MMP-12 is composed of an propeptide domain, a catalytic domain and hemopexin-like domain. The function of MMP-12 include the genetic transcription and inhibitor regulation. Overexpress of MMP-12 causes pathological extracellular matrix protein breakdown and excessive airway remodeling,and MMP-12 is impotant in the pathogenesis of the acute and chronic lung injury,which has been implicated in a range of respiratory diseases, including asthma and emphysema.

作者杨宁(综述)

机构地区山东省德州市人民医院儿科

出处《国际儿科学杂志》 2010年第6期582-584,共3页 International Journal of Pediatrics

关键词基质金属蛋白酶-12 细胞外基质肺疾病 Matrix matalloprotenases-12 Extracellular matrix Pulmonary disease

分类号 R593.22 [医药卫生—内科学]

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