国产依普利酮对家兔急性心肌梗死后心功能的影响

Effects of eplerenone on cardiac function of experimental rabbits after acute myocardial infarction

目的探讨依普利酮对家兔心肌梗死后心功能的影响。方法家兔22只,开胸结扎冠状动脉左心室支制成急性心肌梗死(AMI)动物模型,制模成功后随机分为治疗组与对照组,治疗组家兔给予依普利酮治疗,对照组无药物干预,4周后检测2组各项心功能指标的改变,评价依普利酮对家兔AMI后心功能的影响。结果 18只家兔制模成功,4周后与对照组比较,依普利酮明显改善家兔左心室射血分数(LVEF),显著降低左心室舒张末压(LVEDP),差异有统计学意义(P<0.05)。结论依普利酮可明显改善家兔AMI后的心功能。

Objective To investigate the effects of eplerenone on heart function of experimental rabbits after acute myocardial infarction. Methods The animal models of acute myocardial infarction were made in 22 rabbits by coronary left anterior descending artery ligation. Then the rabbits were randomly divided into two groups： eplerenone group and control group. The rabbits in eplerenone group were treated with eplerenone, however, the rabbits in control group were treated with placebo. After 4 weeks, the heart function indexes were measured by uhrasonocardiography （UCG） for both groups, and all the data were analyzed with SPSS 11.0 software. Results Totally, 18 rabbit models were established successfully. The UCG examination showed that eplerenone increased the value of LVEF and decreased the value of LVEDP significantly, and there were significant differences between the two groups （ P 〈 0.05 ）. Conclusion Eplerenone can improve obviously the heart function in experimental rabbits after acute myocardial infarction.