金属硫蛋白在食管癌和胃癌及大肠癌中表达的临床意义

The expression and clinical significance of metallothionein in esophageal carcinoma,gastral cancer and large intestine cancer

目的探讨金属硫蛋白在食管鳞状细胞癌、胃腺癌、大肠癌中的表达及意义。方法利用SP免疫组织化学技术,检测194例消化管癌组织中金属硫蛋白(MT)表达率。结果 MT在消化管癌总阳性率为58.76%(114/194)。在食管癌、胃癌、肠癌中的阳性率分别为75.00%(24/32),52.27%(46/88),59.46%(44/74)。癌组织浸润深和淋巴结转移者,MT阳性率高于浸润浅组和无淋巴结转移者(P<0.05)。结论 MT表达与癌组织浸润深度和淋巴结转移有关。检测癌组织中MT阳性表达率可以为制定化学治疗方案提供依据。

Objective To observe the expression of metallothionein （MT） in alimentary canal carcinomas. Methods The expression of MT in 194 patients with alimentary canal carcinomas was detected by SP immunohistoehemical method. Results The positive rate of MT was 58.76% （ 114/194 ） in alimentary canal calclnomas. The positive rates in esophageal carcinoma, gastral carcinoma and large intestine carcinoma were 75.00% （24/32）, 32.27% （46/88） and 59.46% （44/74） respectively. The expressions of MT in tumor depth infiltration and lymph node metastases group were significantly higher than those in shallow infiltration and no-lymph node metastases group （ P 〈 0.05 ）. Conclusion The expression of MT is related with the depth of carcinoma tissue infiltration and lymph node metastases. The detection of the expression rate of MT in carcinoma tissue can provide basis for drawing up chemotherapy protocol.