压力性溃疡中药组方抗炎镇痛的药理作用研究

Study on pharmacologic actions of traditional Chinese formula on pressure ulcer

目的 探讨压力性溃疡中药组方的抗炎镇痛作用机理.方法 实验动物应用随机数字表进行随机分组,设中药组方高剂量组、低剂量组,以吲哚美辛组、生理盐水组为对照,通过抑制大鼠角叉菜胶性足跖肿胀实验、醋酸致小鼠腹腔毛细血管通透性实验、醋酸致小鼠扭体反应实验,观察检测受试动物的各项指标.结果 大鼠趾部皮下注射角叉菜胶致炎后,中药组方高剂量组1～6 h足跖肿胀明显低于生理盐水组（P＜0.05）,2～6 h抗炎作用与吲哚美辛组无统计学意义（P＞0.05） 中药组方高剂量组和低剂量组小鼠腹腔染料渗出减少,与生理盐水组比较,差异有统计学意义（P＜0.05）,中药组方高剂量组与吲哚美辛组比较作用强度相当（P＞0.05） 中药组方高剂量组和低剂量组小鼠扭体反应次数与生理盐水组比较显著减少（P＜0.05）.结论 中药组方高低剂量均有抗炎镇痛作用,作用呈量效正相关.

Objective To discuss the anti-inflammatory and analgesic effects of traditional Chinese formula （TCF）on pressure ulcer. Methods The experimental animals were randomly divided into TCF high-dose group, TCF low dose group, indomethacin group, and saline group. through the inhibition of rat carrageenin paw edema test, acetic acid-induced small murine peritoneal capillary permeability experiments, acetic acid-induced writhing response in mice experiments,subjects observe the animals indicators. Results Rat plantar subcutaneous injection of carrageenan-induced inflammation,the compound traditional Chinese medicine set of square high-dose group 1 ～6 h paw edema was significantly lower than saline control group （P〈0.05）, 2～6 h anti-inflammation and indomethacin Xin was no significant difference （P〉0.05） compound Chinese medicine set of square high-dose group and low dose group mice dye leakage reduction compared with the saline group was statistically significant （P〈0.05）, high-dose group and the indomethacin group effect was no significant difference in strength （P〉0.05） compound Chinese medicine set of square high-dose group and low dose group the number of writhing response in mice compared with saline significantly reduce（P〈0.05）. Conclusion Prescription medicine compound high-dose, low dose has anti-inflammatory effects, analgesic effects, Pharmacological effect was dose-proportional relationship.