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运动对胰岛素抵抗骨骼肌AMPK/SIRT1/PGC-1α轴影响的研究述评 被引量：5

Review of the research on the effects of exercising on insulin resisting the AMPK/SIRT1/PGC-1α axis in skeletal muscle
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摘要 SIRT1(沉默信息调节因子2相关酶I)是依赖于辅酶NAD+的去乙酰化酶,不仅与衰老、凋亡、DNA修复有关,还与不同营养应激状态的细胞代谢转换相关。SIRT1和AMPK(腺苷酸活化蛋白激酶)是细胞内的能量感受器,通过磷酸化、去乙酰化调节着PGC-1α的活性。骨骼肌AMPK/SIRT1/PGC-1α轴的活性调控直接影响着其下游相关基因的表达,与胰岛素抵抗的发生与发展密切相关。 Silent information regulation factor 2 related enzyme I （SIRT1） is a coenzyme NAD＋ dependent deacetylase, not only related to aging, dying and DNA repairing, but also correlative with cellular metabolic transformation in different nutrition stress states. SIRT1 and AMPK are energy receptors in cells, regulating the activity of PGC- 1α by means of phosphorylation and deacetylation. The regulation of the activity of the AMPK/SIRT 1/PGC- 1α axis directly affects the expression of its downstream genes related, being closely related to the occurrence and development of insulin resistance.
作者 赵军 徐晓阳 付强
机构地区 暨南大学体育部 华南师范大学体育科学学院 暨南大学华侨医院
出处 《体育学刊》 CAS CSSCI 北大核心 2010年第11期106-110,共5页 Journal of Physical Education
关键词 运动生物化学 胰岛素抵抗 骨骼肌 腺苷酸活化蛋白激酶 沉默信息调节因子2相关酶I 过氧化物酶体增殖物激活受体γ辅激活子1α 综述 sports biochemistry insulin resistance skeletal muscle AMPK SIRT1 PGC-1α summary
分类号 G804.2 [文化科学—运动人体科学]
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参考文献35

  • 1Kelley D E, Mandarino L J. Fuel selection in human skeletal muscle in insulin resistance: a reexamination[J]. Diabetes, 2000, 49(5): 677-683.
  • 2Petersen K F, Dufour S, Befroy D, et al. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes[J]. N Engl J Med, 2004, 350(7) : 664-671.
  • 3Itani S I, Ruderman N B, Schmieder F, et al. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha[J]. Diabetes, 2002, 51(7): 2005-2011.
  • 4He J, Watkins S, Kelley D E. Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity[J]. Diabetes, 2001, 50(4): 817-823.
  • 5Horn F G, Goodner C J. Insulin dose-response characteristics among individual muscle and adipose tissues measured in the rat in vivo with 3[H]2-deoxyglucose[J]. Diabetes, 1984, 33(2): 153-159.
  • 6Pfister J A, Ma C, Morrison B E, et al. Opposing effects of sirtuins on neuronal survival: SIRT 1-mediated neuroprotection is independent of its deacetylase activity[J]. Plos One, 2008, 3(12): e4090.
  • 7Saunders L R V. Cell biology: stress response and aging[J]. Science, 2009, 323(5917): 1021-1022.
  • 8Canto C, Gerhart-Hines Z, Feige J N, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity[J]. Nature, 2009, 458(7241): 1056-1060.
  • 9Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-lalpha[J].Cell, 2006, 127(6): 1109-1122.
  • 10Davis J M, Murphy E A, Carmichael M D, et al. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance[J]. Am J Physiol Regul Integr Comp Physiol, 2009, 296(4): R1071-1077.

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体育学刊
2010年 第11期

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