血清标志物联合检测在急性冠脉综合征临床诊断中的意义

DIAGNOSTIC SIGNIFICANCE OF JOINT DETECTION OF SERUM SYMBOL IN ACUTE CORONARY SYNDROME

目的探讨联合检测心肌肌钙蛋白T(cTn T)、CK、CK-MB和ECG对诊断急性冠脉综合征的临床意义。方法选择入院后172例急性冠脉综合征(ACS)患者与60例健康体检者,实验室检测cTn T、CK、CK-MB和ECG,对ACS患者随访一年,观察其临床并发症及预后情况,进行统计学回顾性分析。结果 ACS组血清单独检测cTn T、CK、CK-MB、ECG阳性率分别为83.1%、74.4%、76.2%、61.6%,与正常对照组相对应的指标结果比较具有显著性差异(p<0.01);ACS组联合检测的阳性率为94.7%,高于cTn T、CK、CK-MB和ECG单独检测的平均水平,其中与ECG单独检测的具有显著性差异(p<0.01)。cTn T和ECG阳性检测对ACS患者的病情发展和预后具有指导意义。结论联合诊测cTn T、CK、CK-MB和ECG能够提高诊断急性冠脉综合征的检出率,拓宽诊断时间窗,明显减少诊断误差,对评估ACS患者的远期预后具有指导作用。

Objective To explore the clinical value of Joint detection of cardiac troponin T（cTn T）、CK、CK-MB and ECG in Acute coronary syndrome（ACS）.Methods Serum of 172 ACS patients and 60 healthy people were examined for cT-nT、CK、CK-MB and ECG,One-year follow-up of patients,then observed the clinical complications and prognosis.Results In ACS group,concentrations of cTn-T（83.1%）、CK（74.4%）、CK-MB（76.2%） and ECG（61.6%） were significantly higher than those in control group（p〈0.01）.The positive rate of combined detection with cTn T、CK、CK-MB and ECG was 94.7%,higher than the average level of the first four items,also higher than ECG（p〈0.01）.Contacted with the positive test on cT-nT and ECG,can advise the development and prognosis of the disease.Conclusion Joint detection of cTn T、CK、CK-MB and ECG in ACS in early stage can elevate ACS diagnosing rate,achieve a wider diagnostic time window,significantly reduced diagnostic errors,assess long-term prognosis of patients with ACS,playing a guiding role.