阻塞性睡眠呼吸暂停低通气综合征患者血清炎性因子的变化及意义

The clinical significance and changes of serum proinflammatory cytokines in Obstructie sleep apnea hypoventilation syndrome patients

目的:探讨白介素-6(IL-6)、高敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)病理生理过程中的意义。方法:检测轻、中重度OSAHS患者及单纯鼾症患者血清IL-6、hs-CRP、TNF-α,中重度患者经韩-腭咽成形术(H-UPPP)治疗前后的IL-6、hs-CRP、TNF-α含量变化。结果:三组IL-6水平无显著性差异;轻、中重度组患者血清hs-CRP水平均显著高于对照组(P<0.05),中重度组患者血清hs-CRP显著高于轻度组(P<0.05);中重度组患者血清TNF-α水平均显著高于对照组(P<0.05)。经H-UPPP术后3个月后,中重度组患者睡眠质量显著改善,AHI显著降低,与治疗前比较有显著性差异(P<0.05),夜间低氧明显改善,血清hs-CRP、TNF-α水平显著降低,与治疗前比较,有显著性差异(P<0.05)。结论:炎性因子可能参与了OSAHS的发生发展过程,经H-UPPP治疗后,炎性因子的浓度下降。

Objective： To investigate the clinical significance and changes of intedeukin （ IL - 6 - 6 ）, gao min C - c - reactive protein （ hs）, the CRP - tumor necrosis factor （TNF alpha （alpha） in obstructive sleep apnea hypoventilation syndrome （OSAHS） in the process of pathophysiology. Methods：To detect the changes of interleukin （IL- 6 -6 ） ,gao rain C -c -reactive protein （hs）, the CRP -tumor necrosis factor （TNF alpha （alpha） in Obstructie sleep apnea hypoventilation syndrome patients, to observe the changes of interleukin （IL- 6- 6） ,gao rain C -c -reactive protein （hs）, the CRP- tumor necrosis factor （TNF alpha （alpha） in Obstructie sleep apnea hypoventilation syndrome patients before and after Korea -up3 angioplasty （UPPP） treatment. Results：Three groups of IL -6 level showed no significant differences, Light, moderate to severe patients serum hs - CRP levels were significantly higher than those in control group （ P 〈 0.05 ）, moderate to severe patients serum hs - CRP is significantly higher than mild group （ P 〈 0.05）. Severe patients＇serum TNF alpha levels were significantly higher than those in control group （ P 〈 0. 05 ）. After UPPP H - 3 months after surgery patients, moderate to improve sleep quality and significantly reduced, and the treatment of AHI before was significant difference （ P 〈 0.05 ）, night low oxygen improved obviously serum hs TNF alpha - CRP and significantly reduced, and treatment level before, significant difference （ P 〈 0.05 ）. Conclusion ：inflammatory factor may be involved in the process of development, the concentration of inflammatory factor was lower after OSAHS after UPPP treatment.