跨膜蛋白16A:钙激活氯通道的最新进展

TMEM16A:Advances in Calcium-activated Chloride Channel

钙激活氯离子通道(calcium-activated chloride channels,CaCCs)介导了众多生理过程,包括跨上皮离子与液体分泌、心肌和神经兴奋、感觉传导、平滑肌收缩和受精过程等,但目前对于其分子基础等重要问题尚未研究清楚.综述了最新报道的CaCCs分子基础跨膜蛋白16A(TMEM16A)的发现过程、基因结构和功能、离子通道电生理特性、相关病理与药理功能的一些热点问题,并展望了该研究领域的发展趋势.

Calcium（Ca^2＋） -activated chloride channels play fundamental roles in numerous physiological processes including transepithelial ion/fluid secretion,cardiac and neuronal excitation,sensory transduction,smooth muscle contraction and fertilization,etc.Despite their physiological importance,the molecular identity of CaCC has not fully invested till now.Here the newly discovered CaCCs molecular basis TMEM16A was reviewed in the respects of the identification processes,gene structure and functions,ion channel’s electrophysiological characters,related diseases,pharmocoligical functions and other current hot issues in the fields.The developmental trends of this field were discussed.