LASP-1研究进展

Progress in The Research of LASP-1

LASP-1(LIM and SH3protein1)最初是由乳腺癌转移性淋巴结cDNA文库中筛选克隆得到,含有LIM和SH3两个结构域.LASP-1在乳腺癌和卵巢癌等多种恶性肿瘤中高表达,并和肿瘤发生、侵袭和转移密切相关.近年来研究还证实LASP-1是抑癌基因p53的靶蛋白.目前的研究均表明LASP-1是一种新的肿瘤转移蛋白.

The LASP-1 gene was initially identified from a cDNA library of metastatic axillary lymph nodes（MLN） from human breast cancer.The Lasp-1 gene encoded a putative protein containing a LIM motif at its amino terminus and a src homology 3（SH3） domain at its C-terminal part.Overexpression of LASP-1 has been reported in many kinds of malignant tumors,such as breast cancer and ovarian cancer.LASP-1 is closely related to genesis,invasion and metastasis of tumor.Recently,LASP-1 was identified as a novel transcriptional target of tumor suppressor gene p53.On the basis of the existing data,LASP-1 is a novel tumor suppressor protein.