APRI与肝硬化食管静脉曲张相关性研究

Study on the clinical correlations between the ratio index APRI and esophageal varices degree of cirrhosis

目的探讨APRI数值与肝硬化静脉曲张的相关性。方法对54例肝硬化伴有食管静脉曲张患者静脉曲张程度进行分级,同时检测AST和PLT,计算AST与PLT比值指数(APRI)。比较不同程度食管静脉曲张分级与APRI间的相关性,并对肝硬化患者有/无食管静脉曲张的APRI进行对比研究。结果不同分级食管静脉曲张患者比较,PLT在G0与G2之间差异有统计学意义(P<0.05),在G0与G3之间差异有统计学意义(P<0.01),在G1与G3之间差异有统计学意义(P<0.01);APRI在G0与G2、G0与G3之间差异有统计学意义(P<0.05);对于AST、PLT、APRI,有/无食管静脉曲张患者之间进行比较,差异具有统计学意义(P<0.05,P<0.01),其余均无统计学意义。结论 APRI可作为预测肝硬化患者食管静脉曲张的诊断指标之一。

Objective To explore the clinical correlations between the ratio index APRI and Esophageal Varices degree of cirrhosis.Methods Fifty-four cirrhosis patients with esophageal varices were retrospectively studied. The esophageal varices grading were assessed. Independent-samples T test was used for comparisons of serum aspartate aminotransferase （AST） levels,blood platelet counts （PLT）,APRI among different esophageal varices grading （G0 to G3）. Results Comparison between various esophageal varices degree show that there were significant differences between G0 and G2 in PLT （P〈0.05）,and also significant differences between G0 and G3 （P〈0.01）. There was a significant difference between G1 and G3 （P〈0.01）; There were significant diferences in AST,PLT and APRI between G0 and G2,G0 and G3 （P〈0.05）,There were significant diferences in AST,PLT and APRI between esophageal varices patients and the others （P〈0.05,P〈0.01）. Conclusion APRI could be one of the diagnose index for prediction Esophageal Varices.