盲法研究细菌性胶原酶对创伤感染的影响

Effects of Bacterial Collagenase on Wound Infection via Blind Means

目的探讨细菌性胶原酶对创口感染情况的影响。方法 2006年11月-2006年12月,对28只新西兰兔分为实验组和对照组,分别予细菌性胶原酶溶液及生理盐水浸润创口并缝合。观察创口感染及局部皮肤的炎性细胞浸润情况。结果实验组与对照组创口感染率差别无统计学意(P>0.05),炎性细胞差别无统计学意义(P>0.05)。结论细菌性胶原酶在创伤修复过程中不能直接降低感染率,对炎性细胞的迁移并无明显的作用。

Objective To assess the effects of bacterial collagenase on the wound infection.Methods A total of 28New Zealand rabbits have chosen from November to December 2006,and were divided into a laboratorial group and a control group.We sutured the wounds and soaked them by the bacterial collagenase liquid or by the physiologic saline solution.The infection and the inflammatory cells of the skin around the wound were observed.Results The difference of the infection rates between the two groups was not statistically significant（P=0.62）,nor the difference of inflammatory cells（P=0.84）.Conclusions Bacterial collagenase can not decrease the rate of infection directly,and had no obvious effect on the transferring of inflammatory cells.