丙泊酚在重症监护室术后患者中的应用

The Application of Propofol in the Patients after Surgical Operation in Intensive Care Unit

目的观察丙泊酚在重症监护室(ICU)外科术后对患者的镇静效果及作用。方法 2006年7月-2008年7月,对行外科手术后在ICU观察室采用丙泊酚镇静的45例患者的镇静效果、停药苏醒时间及给药前后呼吸、循环参数的变化进行观察,并与治疗前进行比较。结果丙泊酚镇静起效快,镇静治疗后大多数患者开始血压有所下降(P<0.05)但不久恢复正常,所有患者心率、呼吸频率、血氧饱和度无明显变化(P>0.05),停药后苏醒快。结论丙泊酚是外科术后患者较理想的镇静剂,但应根据患者情况调整给药速度、剂量及时间。

Objective To observe the sedative effect of propofol on the patients after surgical operations in intensive care unit（ICU）.Methods Forty-five patients underwent the injection with propofol after surgical operations in ICU from July 2006to July 2008.The sedative efficacy,recovery time after the propofol administration,and changes of respiratory,circulate parameter before and after medication were observed,which were compared with those before the treatment.Results The sedative reactive time of propofol was short.Most of the patients had decreased blood pressure after injection with propofol（P〈0.05）but recovered soon.The heart rate,respiratory rate,and pulse oxygen saturation did not significantly changed（P〉0.05）.The recovery time was short after propofol administration was stopped.Conclusion Propofol is an effective sedative for the patients after surgical operations in ICU,but the medicated speed,amount and time according to state of the patients should be adjusted.