摘要
目的分析成都市近年一线抗结核药的耐药状况,为耐药结核病预防控制提供依据。方法对成都市2007年1月-2009年12月就诊的结核患者,临床分离株培养鉴定为结核分枝杆菌的菌株采用绝对浓度法进行一线抗结核药:链霉素(SM)、异烟肼(INH)、利福平(RF)、乙胺丁醇(EMB)耐药性检测,分析结核分枝杆菌的耐药情况。结果 1235例结核患者中,总耐药率和总耐多药率分别为28.83%、14.01%,初始耐药率和获得性耐药率分别为12.82%、61.27%。近3年耐多药率有下降趋势,但获得性耐药率呈逐年上升趋势。结论成都市结核耐药状况仍然比较严重,进一步加强耐药结核的监测和控制非常重要。
Objective To analyze the drug resistant treating mycobacterium tuberculosis(MTB)in Chengdu in recent three years,and to provide the evidence for tuberculosis controlling.Methods The patients with MTB diagnosed from January 2007to December 2009in Chengdu were enrolled.Absolute concentration method was used to test the drug-resistance of streptomycin(SM),isoniazide(INH),rifampicin(RFP),and ethambutol(EMB).Results The total rate of drug resistance and multi-drug resistance were 28.83%and 14.01%respectively.The rates of initial drug resistance and the acquired drug resistance were 12.88%and 61.27%respectively.Multi-drug resistance rate showed a downward trend,but the rate of acquired drug resistance increased gradually.Conclusion The situation of drug resistance of tuberculosis in Chengdu is still serious,and it’s very important to further monitor and control the drug resistance treating tuberculosis.
出处
《华西医学》
CAS
2010年第10期1854-1856,共3页
West China Medical Journal
基金
四川省教育厅课题资助(07ZC010)
关键词
结核
分枝杆菌
初始耐药
获得性耐药
耐药性
Tuberculosis; Mycobacterium; Initial drug resistance; Acquired drug resistance; Drug resistance