中性粒细胞相关载脂蛋白表达与胃癌进展、转移及预后的关系

The Correlation of NGAL and Clinicopathologic Progress, Metastasis and Prognosis in Gastric Carcinoma

目的:探讨中性粒细胞相关载脂蛋白(NGAL)在胃癌组织中的表达及与胃癌进展、转移及预后的关系。方法:应用免疫组化法检测NGAL在102例胃癌、32例正常胃组织中的表达,分析其与胃癌临床病理特征及预后的关系。结果:NGAL在胃癌组织中的阳性表达率为56.9%,明显高于在正常胃组织中的21.9%(χ2=11.938,P<0.01),不同胃癌组织学分型患者NGAL阳性表达差异有统计学意义(χ2=10.180,P<0.05),胃癌患者NGAL表达与浆膜侵犯、TNM分期、淋巴结转移以及T分期呈正相关(rs分别为0.307、0.211、0.220、0.201,P<0.05或P<0.01)。NGAL表达阳性组和阴性组5年累积生存率分别为24.3%和43.7%,差异有统计学意义(P=0.018)。结论:NGAL在胃癌中表达上调,与胃癌进展和淋巴结转移显著相关,提示预后不良,可作为评价胃癌预后新的生物学指标。

Objective： To investigate the expression of neutrophil gelatinase-associated lipocalin （NGAL）,and the correlation of NGAL with clinicopathologic progression, metastasis and prognosis in gastric carcinoma. Methods：The expression of NGAL was observed in 102 gastric carcinoma tissues and 32 normal gastric tissues by immunohistochemistry. The correlation of NGAL expression with clinicopathologic parameters and metastasis was analyzed. Results：The positive rate of NGAL expression was 56.9% in gastric carcinoma, which was significantly higher than that in normal gastric tissue （21.9% , χ2 = 11.938, P 0.01）. The expression of NGAL was significantly different in patients with different histological types （ χ2 = 10.180, P 0.05）. The expression of NGAL was observed to correlate positively with serosal invasion, TNM stage, lymph node status and T stage （rs = 0.307, 0.211, 0.220 and 0.201, P 0.01 or P 0.05）. The five-year cumulative survival rates were 24.3% and 43.7% in the positive and negative NGAL expression groups. Kaplan-Meier curves showed a significant difference （P = 0.018）. Conclusion： NGAL expression was up-regulated in gastric carcinoma, which was significantly correlated with tumor progression and lymphatic metastasis. The expression of NGAL might be a novel molecular marker to predicate the prognosis of gastric carcinoma.